Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which ...

Researchers at University of Tsukuba have achieved high-resolution visualization of cellular organelles, such as nuclei and mitochondria, using an external apodized phase contrast (ExAPC) microscope.

Hosts of new applications have turned the light microscope into an exquisitely sensitive measuring device that can be used to image dynamic cellular events right down to the molecular level. Indeed, ...

A new purpose-built microscope has been developed that uses the complex properties of UV light to improve image resolution and contrast. Most cells are transparent at visible wavelengths, which means ...

(A) When a traditional Gaussian beam is used, diffraction causes the illumination beam to widen at the edges. (B) Joint optimization scheme. A network predicts the positions of beads in the focal ...